Chloroform → HCID 19914474, compound

Participants

Reaction Steps

In a mixed solvent of methanol (9 ml) and chloroform (1 ml) was dissolved 5-benzyloxy-6-methoxy-4(1H)-quinolone (120 mg). To this solution was added 10% palladium-carbon (50 mg), and the mixture was stirred under a stream of hydrogen at room temperature for 2 hours. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. The crude product thus obtained was recrystallized from chloroform-methanol-n-hexane to obtain 5-hydroxy-6-methoxy-4(1H)-quinolone hydrochloride (a salt of compound 1, 73 mg).

Provenance & Evidence