Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1090128Generated: October 27, 2026

Diethyl (ethoxymethylene)malonate → 6,7-Dimethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

https://huagongshe.com/reaction/1090128

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl (ethoxymethylene)malonateHCID 6871—
Reactant3,4-DimethoxyanilineHCID 22770—
Product6,7-Dimethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl esterHCID 1003914940.5%

Reaction Steps

3,4-Dimethoxyaniline (3.0 g) and diethyl ethoxymethylenemalonate (5.1 g) were subjected to condensation and ring closure in the same manner as in Experimental Example 1 to give 6,7-dimethoxy-3-ethoxycarbonyl-4(1H)-quinolone (2.2 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05081121
Source datasetuspto-grants-1992_01
ORD IDord-bfdb5d2a54a647f4862cd76f4cdd5012
Source noteuspto-grants-1992_01