HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → Ethyl 6,7-diethoxy-4-hydroxyquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 3,4-Diethoxyaniline | HCID 520936 | — |
| Product | Ethyl 6,7-diethoxy-4-hydroxyquinoline-3-carboxylate | HCID 12399898 | 69% |
Reaction Steps
3,4-Diethoxyaniline (3.7 g) and diethyl ethoxymethylenemalonate (5.3 g) were reacted in the same manner as in Experimental Example 1 to obtain 6,7-diethoxy-3-ethoxycarbonyl-4(1H)-quinolone (4.3 g). The compound (3 g) was subjected to hydrolysis and decarboxylation in the same manner as in Experimental Example 2 to obtain 6,7-diethoxy-4(1H)-quinolone (compound 10, 1.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05081121 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-5bac4142372f4589b3c7dbb055691d77 |
| Source note | uspto-grants-1992_01 |