Diethyl (ethoxymethylene)malonate → HCID 19914495, compound

Participants

Reaction Steps

4-Benzyloxy-2-methoxyaniline (2.9 g) and diethyl ethoxymethylenemalonate (2.7 g) were reacted in the same manner as in Experimental Example 1 to obtain 6-benzyloxy-3-ethoxycarbonyl-8-methoxy-4(1H)-quinolone (3.5 g). The compound (2.0 g) was subjected to hydrolysis and decarboxylation in the same manner as in Experimental Example 8 to obtain 6-benzyloxy-8-methoxy-4(1H)-quinolone (compound 26, 1.0 g).

Provenance & Evidence