Iodoethane → HCID 15675258, compound

Participants

Reaction Steps

7-Ethoxy-6-methoxy-4(1H)-quinolone (compound 62, 0.68 g) was dissolved in dimethylformamide (14 ml). Potassium carbonate (640 mg) and ethyl iodide (0.3 ml) were added to the solution, and the mixture was stirred at room temperature for 4 hours. The precipitate was removed by filtration, and the filtrate was purified by silica gel column chromatography (Wako Gel C-200, 50 g). Elution with a mixed solvent of chloroform (90 parts) and methanol (10 parts) gave 7-ethoxy-1-ethyl-6-methoxy-4(1H)-quinolone (compound 58, 0.4 g).

Provenance & Evidence