Diethyl (ethoxymethylene)malonate → HCID 19914490, compound

Participants

Reaction Steps

2-Ethoxy-4-methoxyaniline (2.2 g) and diethyl ethoxymethylenemalonate (2.9 g) were reacted in the same manner as in Experimental Example 1 to give 8-ethoxy-3-ethoxycarbonyl-6-methoxy-4(1H)-quinolone (2.9 g). The compound (1.5 g) was N-ethylated with potassium carbonate (2.1 g) and ethyl iodide (4.0 g) in the same manner as in Experimental Example 9 to give 8-ethoxy-3-ethoxycarbonyl-1-ethyl-6-methoxy-4(1H)-quinolone (compound 78, 1.3 g).

Provenance & Evidence