2-Furancarbonyl chloride → HCID 19914480, compound

HRID 1090142Notes

Reaction equation

HRID 1090142 reaction equation
[C:1]([C:4]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:5]=1[NH2:6])(=[O:3])[CH3:2].[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20](Cl)=[O:21]>>[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20]([NH:6][C:5]1[CH:7]=[C:8]([O:13][CH3:14])[C:9]([O:11][CH3:12])=[CH:10][C:4]=1[C:1](=[O:3])[CH3:2])=[O:21]

Participants

3

Reactant 2

HCID 682422-Furancarbonyl chlorideHCID 602085Ethanone, 1-(2-amino-4,5-dimethoxyphenyl)-

Product 1

HCID 19914480HCID 19914480, compoundYield 99%

Procedure

2-Acetyl-4,5-dimethoxyaniline (300 mg) and 2-furoyl chloride (260 mg) were reacted in the same manner as in the preparation of compound 95 to obtain N-(2-furoyl)-2-acetyl-4,5-dimethoxyaniline (440 mg). The compound (380 mg) and potassium t-butoxide (740 mg) were reacted in the same manner as in the preparation of compound 95 to obtain 6,7-dimethoxy-2-(2-furyl)-4(1H)-quinolone (compound 94, 30 mg).

Sources & evidence

ORD record
ord-1cb58931e9964859a9cd0582add3e206
Source dataset
uspto-grants-1992_01
Patent number
US05081121

Reaction notes

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