HCID 14328501, compound → HCID 14700186, compound

HRID 1090153Notes

Reaction equation

HRID 1090153 reaction equation
[CH3:1][C:2]([CH3:14])([CH3:13])[C:3]([OH:12])([CH2:6][N:7]1[CH:11]=[N:10][CH:9]=[N:8]1)[C:4]#[CH:5].[Cl:15][O-].[Na+]>C(Cl)Cl>[Cl:15][C:5]#[C:4][C:3]([OH:12])([CH2:6][N:7]1[CH:11]=[N:10][CH:9]=[N:8]1)[C:2]([CH3:14])([CH3:13])[CH3:1]

Participants

4

Reactant 2

HCID 14328501HCID 14328501, compoundHCID 23665760Sodium Hypochlorite

Product 1

HCID 14700186HCID 14700186, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

9,65 (50 mmol) of 4,4-dimethyl-3-hydroxy-3-[(1,2,4-triazol-1-yl)-methyl]-1-pentine in 20 ml of methylene chloride are stirred for 3 days with 400 ml (150 mmol) of a solution of sodium hypochlorite at room temperature. The reaction mixture is then extracted by shaking with methylene chloride. After drying the organic phase and stripping off the solvent in vacuo, there are obtained 9.8 g (43 mmol; 86% of theory) of 1-chloro-4,4-dimethyl-3-hydroxy-3-[(1,2,4-triazol-1-yl)-methyl]-1-pentine having a melting point of 88° C.

Workup

  1. extractionThe reaction mixture is then extracted
  2. customAfter drying the organic phase

Sources & evidence

ORD record
ord-28856288eae54f1ab48975aee2af3c39
Source dataset
uspto-grants-1992_01
Patent number
US05081140

Reaction notes

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