Water → HCID 15713258, compound

HRID 1090167Notes

Reaction equation

HRID 1090167 reaction equation
[F:1][CH:2]([F:20])[C:3]1([C:15]([O:17]CC)=[O:16])[CH2:8][C:7](=[CH2:9])[CH2:6][CH:5]([C:10]([O-:12])=[O:11])[N:4]1[CH:13]=[O:14].O>[OH-].[Na+].C(O)C>[F:20][CH:2]([F:1])[C:3]1([C:15]([OH:17])=[O:16])[CH2:8][C:7](=[CH2:9])[CH2:6][CH:5]([C:10]([OH:12])=[O:11])[N:4]1[CH:13]=[O:14]

Participants

5

Reactant 2

HCID 962WaterHCID 86745383HCID 86745383, compound

Product 1

HCID 15713258HCID 15713258, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

0.68 ml of IN sodium hydroxide were added to a solution of 54 mg of the product of Step A in 4 ml of ethanol. The mixture was stirred at ambient temperature for 60 hours. 4 ml of water were added and the pH was neutralized to about 6 with Amberlyst 15 resin After filtering and evporating to dryness the residue was taken up in 8 ml of water and lyophilized to obtain 47 mg of the desired product in the form of its sodium salt.

Workup

  1. filtrationAfter filtering

Sources & evidence

ORD record
ord-e8ec404813c04a2eaa5111c9d3ea4caa
Source dataset
uspto-grants-1992_01
Patent number
US05081135

Reaction notes

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