Hydrochloric Acid → HCID 15713260, compound

Participants

Reaction Steps

1.3 ml of 2N sodium hydroxide were added to a solution of 190 mg of the product of Example 13 (Isomer B) in 7 ml of ethanol and the mixture was stirred at ambient temperature for 30 hours and then neutralized to about pH 5 with 2N hydrochloric acid. After evaporating to dryness, the residue was taken up in 5 ml of water, then chromatographed on Dowex resin followed by elution with water. After evaporation to dryness, 140 mg of the product were taken up in 200 ml of water, filtered and lyophilized to obtain 130 mg of the desired product with a Rf=0.4 Butanol-acetic acid-water (4-2-2).

Provenance & Evidence