1,1'-(Chloromethylene)bis(4-fluorobenzene) → HCID 15100869, compound

Participants

Reaction Steps

100 mg of potassium iodide and 2.9 g of di-(4-fluorophenyl)-chloromethane were added to 1.5 g of the potassium salt of 1-hydroxy-1,2,4-triazole in 100 ml of dimethylformamide and the mixture was stirred for 2 hours at room temperature. The solvent was evaporated off under reduced pressure, after which the residue was taken up with 50 ml of methyl tert-butyl ether and the solution was extracted twice by shaking with water. The organic phase was evaporated down to give 3.3 g of a pale yellow oil, which was chromatographed over a short silica gel column using dichloromethane. The yield was 2.0 g of a pale oil.

Provenance & Evidence