Water → HCID 53876563, compound

Participants

Reaction Steps

To a solution of 5 g of methyl α-(hydroxymethyl)-4-chlorophenylacetate and 3.5 g of methanesulphonyl chloride in 30 ml of anhydrous diethyl ether, cooled at 0° C., a solution of 2.6 g of triethylamine in 10 ml of anhydrous diethyl ether is added dropwise. The temperature is allowed to rise again to room temperature, the reaction mixture is poured into water and is extracted with diethyl ether. The ether solution, washed with water, and dried over Na2SO4, is concentrated under vacuum, to yield 7.2 g of raw product. By crystallization thereof from 5 ml of ethanol, 5.4 g of a white solid product (m.p. 77°-8° C.) is obtained, having the structure indicated in the title of this example.

Provenance & Evidence