HCID 10026206, compound → HCID 10091253, compound

Participants

Reaction Steps

A solution of 6-Isopropyl-3-[4-(benzenesulfonylamino)butyl]-azulene-1-carboxylic acid methyl ester (1.53 g) in 100% phosphoric acid (13 ml) was stirred at 120° C. for 20 min. The reaction mixture was poured on ice-water, and extracted with ethyl acetate. The ethyl acetate extracts were washed with water and dried over MgSO4. Removal of the solvent and the purification by silica gel columnchromatography (ethyl acetate-n-hexane, 1:3) afforded the title compound (1.23 g 94%) as a violet crystal 75°~76° C.

Provenance & Evidence