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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1090193Generated: November 1, 2026

Methyl 2,2-dimethyl-4-oxohexanoate → 3-[1-(4-Chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

https://huagongshe.com/reaction/1090193

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2,2-dimethyl-4-oxohexanoateHCID 13164740—
Reactant1-(4-Chlorobenzyl)-1-(4-methoxyphenyl)hydrazine hydrochlorideHCID 18947569—
Solventtert-ButanolHCID 6386—
Product3-[1-(4-Chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acidHCID 11740819—

Reaction Steps

Following the method of Example 2, but using 1-[(4-chlorophenyl)methyl]-1-(4-methoxyphenyl)hydrazine hydrochloride and methyl 2,2-dimethyl-4-oxohexanoate as the starting materials and tert-butanol as the solvent, the title compound was prepared.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05081145
Source datasetuspto-grants-1992_01
ORD IDord-b4821540da08442fb566b92c11aa08a8
Source noteuspto-grants-1992_01