2,2-Dimethyl-4-oxohexanoic acid → L 655240

HRID 1090200Notes

Reaction equation

HRID 1090200 reaction equation
Cl.[Cl:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)N)=[CH:5][CH:4]=1.[CH3:19][C:20]([CH3:29])([CH2:24][C:25](=O)[CH2:26][CH3:27])[C:21]([OH:23])=[O:22]>C(O)(C)(C)C>[Cl:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:10]3[C:15](=[CH:14][C:13]([F:16])=[CH:12][CH:11]=3)[C:26]([CH3:27])=[C:25]2[CH2:24][C:20]([CH3:29])([CH3:19])[C:21]([OH:23])=[O:22])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 145912352,2-Dimethyl-4-oxohexanoic acidHCID 145912421-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride

Product 1

HCID 122070L 655240

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

Following the method of Example 2, but using 1-[4-chlorobenzyl]-1-(4-fluorophenyl)hydrazine hydrochloride 1.9 g and 2,2-dimethyl-4-oxohexanoic acid (950 mg) as starting materials, in t-butanol as solvent, after 16 hrs. at reflux, the solvent was removed in vacuo, and the title compound was isolated by crystallization and filtration, followed by crystallization from hot ethyl acetate:hexane 9:1.

Workup

  1. temperatureat reflux
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-8021de0329444ea5a9aaca018ad2229f
Source dataset
uspto-grants-1992_01
Patent number
US05081145

Reaction notes

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