1-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride → 3-[1-(4-Chlorobenzyl)-3-methyl-5-fluoroindol-2-yl]-2-methyl-butanoic acid

HRID 1090203Notes

Reaction equation

HRID 1090203 reaction equation
Cl.[Cl:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)N)=[CH:5][CH:4]=1.[CH3:19][CH:20]([CH:26]([CH3:31])[C:27](=O)[CH2:28][CH3:29])[C:21]([O:23]CC)=[O:22]>>[Cl:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:10]3[C:15](=[CH:14][C:13]([F:16])=[CH:12][CH:11]=3)[C:28]([CH3:29])=[C:27]2[CH:26]([CH3:31])[CH:20]([CH3:19])[C:21]([OH:23])=[O:22])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 145912421-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochlorideHCID 15678803Ethyl 2,3-dimethyl-4-oxohexanoate

Product 1

HCID 156788043-[1-(4-Chlorobenzyl)-3-methyl-5-fluoroindol-2-yl]-2-methyl-butanoic acid

Procedure

Following the method of Example 2, but using 1-[4-chlorobenzyl]-1-(4-fluorophenyl) hydrazine hydrochloride and ethyl 2,3-dimethyl-4-oxohexanoate as starting materials, the title compound was prepared.

Sources & evidence

ORD record
ord-8dbea2ba8a034f7eb0e4c2597d7f2db7
Source dataset
uspto-grants-1992_01
Patent number
US05081145

Reaction notes

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