HCID 15678805, compound → HCID 15678806, compound

Participants

Reaction Steps

1.50 g 1-(4-chlorobenzyl)-3-methyl-5-methoxy-1H-indole-2-carboxylate methyl ester was dissolved in 50 ml dry THF. Diisobutyl aluminum hydride (1.5M) in THF (2 equivalents) was added at -78° C. The reaction was stirred for 16 hrs., allowed to reach room temperature and quenched with NH4Cl (aq.). The organic phase was separated, dried (Na2SO4) and evaporated to produce 1.32 g of product which was purified on column chromatography to yield the title compound of Step 2.

Provenance & Evidence