Water → HCID 67917551, compound

Participants

Reaction Steps

The product from Step 2 above (1.0 g) was dissolved in dry DMF (10 ml) at -20° C. Potassium hexamethyl disilazane base in toluene (0.69M) was added (1.1 molar equivalents) and the reaction stirred for 1 hr. Ethyl 2-bromo acetate (580 mg)=1.2 equivalents was added and the reaction stirred for 16 h at 21° C. Water was added (3 ml). The product was isolated after extraction from the aqueous DMF with ether. Following purification on column chromatography, the title ethyl ester was hydrolysed in 3N NaOH according to the procedure in Example 2.

Provenance & Evidence