Fumaric Acid → HCID 178456323, compound

HRID 1090224Notes

Reaction equation

HRID 1090224 reaction equation
Cl.Cl.[N:3]1([CH2:8][CH:9]=[CH:10][CH2:11][NH:12][C:13]2[C:21]3[CH:22]=[CH:23][CH:24]=[C:19]4[C:20]=3[C:15](=[CH:16][CH:17]=[CH:18]4)[N:14]=2)[CH:7]=[CH:6][N:5]=[CH:4]1.[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29]>CC(C)=O>[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29].[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29].[N:3]1([CH2:8]/[CH:9]=[CH:10]\[CH2:11][NH:12][C:13]2[C:21]3[CH:22]=[CH:23][CH:24]=[C:19]4[C:20]=3[C:15](=[CH:16][CH:17]=[CH:18]4)[N:14]=2)[CH:7]=[CH:6][N:5]=[CH:4]1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 178456321HCID 178456321, compound

Product 1

HCID 178456323HCID 178456323, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The free base of the product of Example 10 was dissolved in acetone and added to a boiling solution of two equivalents of fumaric acid in acid. After cooling to room temperature, the bright yellow precipitate of the desired product was collected and dried. It melted at 111° C.-113° C.

Workup

  1. customthe bright yellow precipitate of the desired product was collected
  2. customdried

Sources & evidence

ORD record
ord-5093660e7f404915bd9432dbe2a1ff25
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

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