3-(Trifluoromethyl)benzoyl chloride → HCID 15035084, compound

HRID 1090235Notes

Reaction equation

HRID 1090235 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]2[C:20]3[CH:21]=[CH:22][CH:23]=[C:18]4[C:19]=3[C:14](=[CH:15][CH:16]=[CH:17]4)[N:13]=2)[CH:2]=1.[F:24][C:25]([F:36])([F:35])[C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][CH:34]=1)[C:29](Cl)=[O:30]>N1C=CC=CC=1>[N:13]1[C:14]2[C:19]3[C:18](=[CH:23][CH:22]=[CH:21][C:20]=3[C:12]=1[N:11]([CH2:10][CH2:9][CH2:8][CH2:7][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:29](=[O:30])[C:28]1[CH:32]=[CH:33][CH:34]=[C:26]([C:25]([F:24])([F:35])[F:36])[CH:27]=1)[CH:17]=[CH:16][CH:15]=2

Participants

4

Reactant 2

HCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 178420785HCID 178420785, compound

Product 1

HCID 15035084HCID 15035084, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 5.0 grams of N-(4-(3-pyridinyl)butyl)benz(cd)indol-2-amine in 50 ml of pyridine was stirred as 2.5 ml of 3-trifluoromethylbenzoyl chloride was slowly added. The reaction mixture was stirred at room temperature for 18 hours, and drowned onto 500 ml of ice. The precipitate was collected, washed with water and dried. Recrystallization from chloroform-hexane gave 3.95 grams of the title product, mp 122° C.-123° C.

Workup

  1. additionwas slowly added
  2. customThe precipitate was collected
  3. washwashed with water
  4. customdried
  5. customRecrystallization from chloroform-hexane

Sources & evidence

ORD record
ord-a089b617c02c449eb2b2c3725f92a94f
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

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