HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinemethanol → 2-(Pyridin-3-yloxy)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinemethanol | HCID 7510 | — |
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 14547293 | HCID 14547293 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(Pyridin-3-yloxy)acetonitrile | HCID 19914618 | — |
Reaction Steps
The starting amine, (3-pyridinyl)methyloxyethylamine, was prepared by the following procedure: reaction of the sodium salt of 3-pyridinylmethanol and chloracetonitrile in dimethylformamide gave 2-(3-pyridinyloxy)acetonitrile, which, upon reduction with borane in tetrahydroduran solution, gave the desired amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05081131 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-f651c32dc42d41d5956b9b9d5d8f681f |
| Source note | uspto-grants-1992_01 |