HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanone → N-Cyclohexyl-N-((3-pyridinyl)propyl)benz(cd)indol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanone | HCID 7967 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 3-(Pyridin-3-yl)propan-1-amine | HCID 13557523 | — |
| Reactant | N-cyclohexyl-3-(3-pyridinyl)propanamine | HCID 15035098 | — |
| Reactant | HCID 178527764 | HCID 178527764 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-Cyclohexyl-N-((3-pyridinyl)propyl)benz(cd)indol-2-amine | HCID 15035102 | — |
Reaction Steps
The reaction of 3-(3-pyridinyl)propanamine and cyclohexanone in methanol in the presence of NaBH3CN leads to the preparation of N-cyclohexyl-3-(3-pyridinyl)propanamine. The latter compound, upon reaction with molar equivalents of benz(cd)indol-2-thiol and mercuric acetate in refluxing ethanol under the conditions of Example 55 leads to the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05081131 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-dbe7d8dbca23492c9cf0f90f3e3ca08f |
| Source note | uspto-grants-1992_01 |