HCID 15035099, compound → HCID 15035103, compound

HRID 1090252Notes

Reaction equation

HRID 1090252 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][CH2:10][CH2:11][O:12][CH3:13])[CH:5]=[CH:4][N:3]=[CH:2]1.[N:14]1[C:22]2[C:17]3[C:18](=[CH:23][CH:24]=[CH:25][C:16]=3[C:15]=1S)[CH:19]=[CH:20][CH:21]=2>C(O)C>[N:1]1([CH2:6][CH2:7][CH2:8][N:9]([CH2:10][CH2:11][O:12][CH3:13])[C:15]2[C:16]3[CH:25]=[CH:24][CH:23]=[C:18]4[C:17]=3[C:22](=[CH:21][CH:20]=[CH:19]4)[N:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 15035099HCID 15035099, compoundHCID 178527764HCID 178527764, compound

Product 1

HCID 15035103HCID 15035103, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction of 2-methoxyacetyl chloride and 3-(1H-imidazol-1-yl)propanamine in the presence of triethylamine leads to the formation of N-(3-(1H-imidazol-1-yl)propyl)-2-methoxyacetamide, which by reduction with borane gives N-(3-(1H-imidazol-1-yl)propyl)-2-methoxyethylamine. The latter amine reacts with molar equivalents of benz(cd)indol-2-thiol and mercuric acetate in refluxing ethanol, under the conditions of Example 55 to yield the title compound.

Sources & evidence

ORD record
ord-12bf1905d694414aada58ca2fd8b08fc
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

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