Sodium Hydroxide → HCID 178419796, compound

HRID 1090259Notes

Reaction equation

HRID 1090259 reaction equation
I.[N:2]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]2[C:20]3[CH:21]=[CH:22][CH:23]=[C:18]4[C:19]=3[C:14](=[CH:15][CH:16]=[CH:17]4)[N:13]=2)[CH:6]=[CH:5][N:4]=[CH:3]1.[OH-].[Na+]>ClCCl>[N:2]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]2[C:20]3[CH:21]=[CH:22][CH:23]=[C:18]4[C:19]=3[C:14](=[CH:15][CH:16]=[CH:17]4)[N:13]=2)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178506531HCID 178506531, compound

Product 1

HCID 178419796HCID 178419796, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 41.8 g portion of N-(4-(1H-imidazol-1-yl)butyl)benz(cd)indol-2-amine, monohydroiodide was added to a stirred mixture of 500 ml of dichloromethane and 125 ml of 1N sodium hydroxide solution. After 1 hour the layers were separated and the dichloromethane layer dried over sodium sulfated. The sodium sulfate was filtered off and the filtrate evaporated to dryness in vacuo, giving 29 g of the desired compound as a bright orange yellow viscous oil.

Workup

  1. customAfter 1 hour the layers were separated
  2. dry with materialthe dichloromethane layer dried over sodium
  3. filtrationThe sodium sulfate was filtered off
  4. customthe filtrate evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-e0761872111c447e94e202819b6b64d1
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

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