反应详情

温度

0 °C

0.3 g of 4-hydroxycarbonylazetidine-2-one, 0.43 g of anhydrous sodium acetate and 100 mg of 5% ruthenium-carbon were suspended in a mixture of 12 ml of methylene chloride and 4 ml of acetic acid and cooled to -3° C., to which 1.1 ml of acetic acid solution containing 40% peracetic acid was carefully dropped, subjected to stirring at 0° C. for 1 hour. The catalyst was separated by suction filtration, then solvent was distilled off under reduced pressure. 20 ml of n-hexane was added thereto. Undissolved matter was filtered off, the filtrate was concentrated under reduced pressure to obtain 0.37 g of the title compound (yield: 82%).

1. additionwas carefully dropped
2. customThe catalyst was separated by suction filtration
3. distillationsolvent was distilled off under reduced pressure
4. addition20 ml of n-hexane was added
5. filtrationUndissolved matter was filtered off
6. concentrationthe filtrate was concentrated under reduced pressure