m-Chloroperbenzoic acid → HCID 178490215, compound

Participants

Reaction Steps

2-[[(3-Methoxyphenyl)ethyl]thio]-1H-imidazo[4,5-c]pyridine (4.0 g, 0.014 mol) was dissolved in 60 mL of chloroform and cooled in an ice bath to 0°-5° C. m-Chloroperoxybenzoic acid (3.13 g, 0.015 mol) was added in portions to the reaction mixture. After 45 minutes, 10% aqueous sodium bicarbonate solution was added. The organic layer was removed and dried over magnesium sulfate, filtered and evaporated to dryness in a rotary evaporator. The crude product (4.2 g) when subjected to HPLC gave 2.3 g of pure product, m.p. 125°-128° C.

Provenance & Evidence