反应详情

To a solution of 3.58 g (15.4 mmol) of methyl (-)-3-t-butyldimethylsilyloxybutyrate dissolved in 30 ml of methanol, 30 ml of 1N potassium hydroxide was added and the mixture was stirred for 15 hours. After almost all methanol was distilled away, the resultant was acidified with 1N hydrochloric acid and extracted with diethyl ether. The extract was washed with a saturated solution of NaCl, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 3.18 g of (-)-3-t-butyldimethylsilyloxybutyric acid (yield: 95%).

1. distillationAfter almost all methanol was distilled away
2. extractionextracted with diethyl ether
3. washThe extract was washed with a saturated solution of NaCl
4. dry with materialdried with anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure