Hydrochloric Acid → HCID 19915055, compound

Participants

Reaction Steps

To a solution of 30 mg (0.1 mmol) of 1-benzyl-3-(1-hydroxyethyl)-4-(1-methoxycarbonylethenyl)-2-azetidinone dissolved in 1 ml of methanol, 1 ml (1 mmol) of 1N potassium hydroxide was added with ice bath. After the mixture was stirred at room temperature for 4 hours, 1 ml of 1N hydrochloric acid was added and the extraction with ethyl acetate was conducted three times. The extract was washed with a saturated solution of NaCl, dried with magnesium sulfate and concentrated to give 19 mg of 1-benzyl-4-(1-carboxyethenyl)-3-(1-hydroxyethyl)-2-azetidinone (yield: 68%).

Provenance & Evidence