Methanol → HCID 19915060, compound

Participants

Reaction Steps

To a solution of 38 mg (0.14 mmol) of 1-benzyl-4-(1-carboxyethenyl)-3-(1-hydroxyethyl)-2-azetidinone dissolved in 1 ml of methanol, 5 mg of 5% palladium charcoal was added and the mixture was stirred under hydrogen atmosphere for a night. The reaction solution was filtered with selite, the filtrate was added with an ethereal solution of diazomethane and the resultant was concentrated. The concentrate was purified with 2 g of silica-gel column (benzene:ethyl acetate 1:1) to give 30 mg of 1-benzyl-4-(1-methoxycarbonylethyl)-3-(1-hydroxyethyl)-2-azetidinone (yield: 78%).

Provenance & Evidence