2-Chloropyrimidine → HCID 15682750, compound

HRID 1090337Notes

Reaction equation

HRID 1090337 reaction equation
C1(C([O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH:28]([OH:49])[CH2:29][O:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.Cl[C:51]1[N:56]=[CH:55][CH:54]=[CH:53][N:52]=1>>[CH:43]1([CH2:42][CH2:41][CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][O:30][CH2:29][CH:28]([O:49][C:51]2[N:56]=[CH:55][CH:54]=[CH:53][N:52]=2)[CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][OH:20])[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]1

Participants

3

Reactant 2

HCID 744042-ChloropyrimidineHCID 14877787HCID 14877787, compound

Product 1

HCID 15682750HCID 15682750, compoundYield 83.9%

Procedure

The procedure of Reference Example 2 was applied for a reaction of 2-[2-[3-(12-cyclohexyldodecyloxy)-2-hydroxypropoxy]ethoxy]ethyl triphenylmethyl ether (7.69 g) with 2-chloropyrimidine (3.36 g) to yield the desired compound (4.88 g).

Sources & evidence

ORD record
ord-765b9681ed8848a69f3f6df46629ec8e
Source dataset
uspto-grants-1992_01
Patent number
US05081245

Reaction notes

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