Water → N-dodecylmethanesulfonamide

Participants

Reaction Steps

A mixture of 1-aminododecane (5.67 g, 30 mmol), methanesulfonyl chloride (2.52 ml, 32.6 mmol) and triethylamine (4.5 ml, 32.6 mmol) in dichloromethane (30 ml) was stirred at room temperature for 14 hours. The mixture was poured into water and the layers were separated. Evaporation of the dried (magnesium sulfate) organic layer gave a solid, which after trituration with cold hexane gave the title sulfonamide. 1HNMR(CDCl3): 0.92 (t, 3H, J=7.1 Hz), 1.29 (br s, 18H), 1.60 (2H), 2.99 (s, 3H), 3.16 (dd, 2H, J=13.3 Hz, 6.4 Hz) and 4.25 (br, 1H). HRMS exact mass calculated for C13H30NO2 (M+H)+ 264.1997, found 264.1993.

Provenance & Evidence