反应详情

A mixture of 20.0 g (50 mmol) of 7-[3-(acetylamino)cyclopentyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, ethyl ester was heated in a mixture of 6.0 M hydrochloric acid/ethanol (20 ml/150 ml) at reflux for 8 hours. The solvent was removed in vacuo and the residue slurried in 200 ml of water and filtered. The filtrate was evaporated in vacuo and the residue triturated in ethanol and filtered. The precipitate was washed with ethanol, ether, and dried in vacuo to give 13.6 g of the title compound.

1. temperatureat reflux for 8 hours
2. customThe solvent was removed in vacuo
3. filtrationfiltered
4. customThe filtrate was evaporated in vacuo
5. customthe residue triturated in ethanol
6. filtrationfiltered
7. washThe precipitate was washed with ethanol, ether
8. customdried in vacuo