Potassium tert-butoxide → HCID 14770862, compound

Participants

Reaction Steps

A solution of 21.4 g (50 mmol) of α-[(cyclopropylamino) methylene]-4-(1,4-dioxaspiro[4.4]non-7-yl)-2,5-difluoro-β-oxobenzenepropanoic acid, ethyl ester in 250 ml of dry t-butanol was treated with a slurry of 6.2 g (55 mmol) of potassium t-butoxide in 150 ml of dry t-butanol. The resulting suspension was stirred at 65° for 4 hours and then at room temperature overnight. The solvent was removed in vacuo and the residue was dissolved in methylene chloride and washed with 1.0 M hydrochloric acid. After drying (MgSO4) and evaporating the solvent in vacuo, the residue was recrystallized from ethyl acetate/hexane to give 17.3 g of the title compound.

Provenance & Evidence