Potassium tert-butoxide → HCID 14770828, compound

Participants

Reaction Steps

A solution of 3.49 g (8.30 mmol) ethyl 4-(1-acetyl-4-piperidinyl)-α-[(cyclopropylamino)methylene]-2,5-difluoro-β-oxobenzenepropionate in 35 ml of t-butyl alcohol was treated with 0.93 g (8.30 mmol) potassium t-butoxide and stirred in an oil bath at 65° for 1.5 hours. The mixture was evaporated under vacuum and the residue extracted with 0.5 N hydrochloric acid. The organic layer was dried (MgSO4) and evaporated. The title compound was isolated by chromatography on silica gel and crystallization from toluene, mp 195°-201° C.

Provenance & Evidence