Acetic Anhydride → HCID 14770823, compound

HRID 1090406Notes

Reaction equation

HRID 1090406 reaction equation
Cl.[C:2]([C:5]1[C:10]([F:11])=[CH:9][C:8]([C:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH:17]=2)=[C:7]([F:18])[CH:6]=1)([OH:4])=[O:3].[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:2]([C:5]1[C:10]([F:11])=[CH:9][C:8]([C:12]2[CH2:17][CH2:16][N:15]([C:19](=[O:21])[CH3:20])[CH2:14][CH:13]=2)=[C:7]([F:18])[CH:6]=1)([OH:4])=[O:3]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 14770822HCID 14770822, compound

Product 1

HCID 14770823HCID 14770823, compound

Procedure

A suspension of 8.51 g (29.1 mmol) 4-(4-carboxy-2,5-difluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride in 90 ml acetic anhydride was stirred at reflux for 0.75 hour. The resulting solution was evaporated to dryness and the residue stirred with water, filtered, and crystallized from acetic acid-water to afford the title compound, mp 241°-242° C.

Workup

  1. temperatureat reflux for 0.75 hour
  2. customThe resulting solution was evaporated to dryness
  3. stirringthe residue stirred with water
  4. filtrationfiltered
  5. customcrystallized from acetic acid-water

Sources & evidence

ORD record
ord-c6453690516249f497dde574fa5a6bc6
Source dataset
uspto-grants-1992_01
Patent number
US05081254

Reaction notes

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