Potassium tert-butoxide → HCID 14770829, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4.70 g (11.3 mmol) of ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-4-pyridyl)-α-[(cyclopropylamino) methylene]-2,5-difluoro-β-oxobenzenepropionate in 35 ml of t-butyl alcohol was treated with 1.26 g (11.3 mmol) potassium t-butoxide and stirred in an oil bath at 65° C. for 5.5 hours. The mixture was evaporated under vacuum and the residue was dissolved in chloroform and extracted with 0.5 N hydrochloric acid. The organic layer was dried (MgSO4), evaporated and the title compound purified by chromatograph on silica gel and crystallization from toluene, mp 190°-192° C.

Provenance & Evidence