Ethanol → HCID 14699637, compound

HRID 1090414Notes

Reaction equation

HRID 1090414 reaction equation
[F:1][C:2]1([Cl:9])[CH2:4][C:3]1([CH3:8])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:15](O)[CH3:16]>>[F:1][C:2]1([Cl:9])[CH2:4][C:3]1([CH3:8])[C:5]([O:7][CH2:15][CH3:16])=[O:6]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 14699634128230-79-5

Product 1

HCID 14699637HCID 14699637, compoundYield 79%

Procedure

44 ml of ethanol are added at room temperature and with stirring to 43 g (0.28 mol) of 2-fluoro-2-chloro-1-methyl-cyclopropanecarboxylic acid. After the addition of sulphuric acid, the reaction mixture is refluxed for 16 hours. Excess ethanol is subsequently distilled off and the residue is dried and distilled under reduced pressure. In this manner, 40 g (79% of theory) of ethyl 2-fluoro-2-chloro-1-methyl-cyclopropane-carboxylate are obtained in the form of a liquid of boiling point 62°-63° C./17 mbar.

Workup

  1. temperaturethe reaction mixture is refluxed for 16 hours
  2. distillationExcess ethanol is subsequently distilled off
  3. customthe residue is dried
  4. distillationdistilled under reduced pressure

Sources & evidence

ORD record
ord-454a7881f5974cbea382d5b033bcad1f
Source dataset
uspto-grants-1992_01
Patent number
US05081283

Reaction notes

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