HCID 19915355, compound → HCID 19915368, compound

Under a nitrogen atmosphere, 2.0 grams of 10% palladium on charcoal was weighed into a 500 ml Parr hydrogenation bottle. To the bottle was then added a solution of 11.0 grams (0.037 mole) of 4,6-dibromo-6,6-difluorohexan-1-ol in 75 ml of absolute ethanol. An additional 75 ml of absolute ethanol was used to wash any remaining hexan-1-ol from its container into the hydrogenation bottle. Sodium acetate, 3.1 grams (0.037 mole), was then added to the bottle, and the bottle was placed in the Parr hydrogenator. Upon completion of the uptake of the theoretical amount of hydrogen, the bottle was removed from the hydrogenator, and the contents were filtered. The filtrate was concentrated under reduced pressure to a residual solid. The solid was stirred in 100 ml of pentane, and the mixture was filtered. The filtrate was concentrated under reduced pressure to a residual oil. The oil was purified by column chromatography on silica gel. Elution was accomplished using methylene chloride followed by ethyl acetate. The appropriate fractions were combined and concentrated under reduced pressure yielding 2.0 grams of 6-bromo-6,6-difluorohexan-1-ol. The nmr spectrum was consistent with the proposed structure.

1. washto wash any remaining hexan-1-ol from its container into the hydrogenation bottle
2. additionSodium acetate, 3.1 grams (0.037 mole), was then added to the bottle
3. customUpon completion of the uptake of the theoretical amount of hydrogen, the bottle was removed from the hydrogenator
4. filtrationthe contents were filtered
5. concentrationThe filtrate was concentrated under reduced pressure to a residual solid
6. filtrationthe mixture was filtered
7. concentrationThe filtrate was concentrated under reduced pressure to a residual oil
8. customThe oil was purified by column chromatography on silica gel
9. washElution
10. concentrationconcentrated under reduced pressure

ORD record

ord-f5ff9ac218d2420289a4753560f9d526

Source dataset

uspto-grants-1992_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05081287