Methyl iodide → N-{2-(4-Hydroxypiperidino)-1-[p-(5-isoquinolinesulfonyloxy)benzyl]ethyl)-N-methyl-5-isoquinolinesulfonamide

HRID 1090570Notes

Reaction equation

HRID 1090570 reaction equation
C([O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH:12]([NH:34][S:35]([C:38]2[C:39]3[CH:40]=[CH:41][N:42]=[CH:43][C:44]=3[CH:45]=[CH:46][CH:47]=2)(=[O:37])=[O:36])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][S:21]([C:24]3[C:25]4[CH:26]=[CH:27][N:28]=[CH:29][C:30]=4[CH:31]=[CH:32][CH:33]=3)(=[O:23])=[O:22])=[CH:16][CH:15]=2)[CH2:7][CH2:6]1)(=O)C.[CH3:48]I>>[OH:4][CH:5]1[CH2:6][CH2:7][N:8]([CH2:11][CH:12]([N:34]([CH3:48])[S:35]([C:38]2[C:39]3[CH:40]=[CH:41][N:42]=[CH:43][C:44]=3[CH:45]=[CH:46][CH:47]=2)(=[O:37])=[O:36])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][S:21]([C:24]3[C:25]4[CH:26]=[CH:27][N:28]=[CH:29][C:30]=4[CH:31]=[CH:32][CH:33]=3)(=[O:22])=[O:23])=[CH:16][CH:15]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 131717151N-{2-[4-acetoxypiperidino]-1-[p-(5-isoquinolinesulfonyloxy)benyl]ethyl}-5-isoquinolinesulfonamide

Product 1

HCID 19796382N-{2-(4-Hydroxypiperidino)-1-[p-(5-isoquinolinesulfonyloxy)benzyl]ethyl)-N-methyl-5-isoquinolinesulfonamide

Procedure

The amorphous compound obtained in Example 103 was treated with methyl iodide according to the procedure in Example 89 and the intermediate product was subjected to alkaline hydrolysis according to the procedure in Example 104, to obtain the same product as in Example 99.

Workup

  1. customthe intermediate product was subjected to alkaline hydrolysis
  2. customto obtain the same product as in Example 99

Sources & evidence

ORD record
ord-3d153810520243ec8e9f397d0d8f7124
Source dataset
uspto-grants-1992_01
Patent number
US05081246

Reaction notes

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