Water → HCID 178418479, compound

HRID 1090610Notes

Reaction equation

HRID 1090610 reaction equation
[C:1]([O-:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[Na+].[OH2:11]>>[OH:11][C:5]1[CH:6]=[CH:7][C:2]([C:1]([OH:9])=[O:8])=[CH:3][N:4]=1

Participants

3

Reactant 2

HCID 962WaterHCID 23687810Niacin sodium

Product 1

HCID 178418479HCID 178418479, compound

Conditions

Temperature
30 °C

Procedure

A 3-liter reaction vessel was filled with 2250 ml of 5 percent sodium nicotinate solution (pH 6.5) and was heated to 30° C. A suspension of Achromobacter xylosoxydans DSM 2783 cells in 120 ml of water was added and the reaction mixture was aerated intensively while stirring it well. The pH, the temperature and the oxygen concentration in the reaction mixture were measured and regulated continuously. After 7 hours, the concentration of the dissolved oxygen rose. At this point, the reaction was completed. The reaction suspension was centrifuged off and the cells in the sediment were used for the next charge. The clear supernatant was brought to pH 1.5 with concentrated sulfuric acid and the 6-hydroxynicotinic acid obtained was drained off and dried. 121 g of white product was obtained which, according to HPLC analysis, contained 98.6 percent of 6-hydroxynicotinic acid. This corresponded to a 6-hydroxynicotinic acid yield of 93.7 percent, related to the nicotinic acid used.

Workup

  1. customA 3-liter reaction vessel
  2. additionwas added
  3. concentrationThe pH, the temperature and the oxygen concentration in the reaction mixture

Sources & evidence

ORD record
ord-3c07478c6f7448a2acdbf2f414794b83
Source dataset
uspto-grants-1992_01
Patent number
US05082777

Reaction notes

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