HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-[4-(2-Methyl-2-nitropropylamino)benzoyl]propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Methyl-2-nitro-1-propanol | HCID 6442 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(p-Aminobenzoyl)propionic acid hydrochloride | HCID 67856648 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[4-(2-Methyl-2-nitropropylamino)benzoyl]propionic acid | HCID 15020502 | 87.5% |
Reaction Steps
A mixed solution containing 46 g of 3-(p-amino-benzoyl)propionic acid hydrochloride, 25 g of 2-methyl-2-nitro-1-propanol, 1 g of benzyl triethyl ammonium chloride, 17 g of sodium hydroxide and 40 ml of water was heated under reflux for 6 hours. Then, 12 g of 2-methyl-2-nitro-1-propanol was added, and the mixture was further heated under reflux for 18 hours. Then 20% HCl was added. The solution was acidified (pH 2). The crystals which precipitated were collected by filtration. The crystals were washed with water and recrystallized from tetrahydrofuran to give 51.6 g of 3-[4-(2-methyl-2-nitropropylamino)benzoyl]propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05082844 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-4a19c9bab12f484cbf810401e4a361fd |
| Source note | uspto-grants-1992_01 |