反应详情

A mixture of 3-butyryl-4-chloro-8-phthalimidoquinoline (61.6 g, 0.16 moles) and o-toluidine (20 ml, 0.19 mol) was heated under reflux in 1,4-dioxan (300 ml) for 3 hours. The solvent was evaporated and the residue was dissolved in chloroform, washed with dil. ammonia solution and brine. The organic solution was dried (anhyd. MgSO4) filtered and evaporated to a dark oil which crystallized on standing to give 3-butyryl-4-(2-methylphenylamino)-8-phthalimidoquinoline (42 g, 58.3%), m.p. b 170°-2° C.

1. temperaturewas heated
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in chloroform
4. washwashed with dil. ammonia solution and brine
5. dry with materialThe organic solution was dried (anhyd. MgSO4)
6. filtrationfiltered
7. customevaporated to a dark oil which
8. customcrystallized