2-Hydroxyquinoline → Hydrocarbostyril

Participants

Reaction Steps

A carbostyril of Formula 14 is hydrogenated, e.g., in a mixture of methanol/acetic acid, or preferably in N-methylpyrrolidinone, with a palladium hydroxide catalyst at elevated temperature (e.g., 40° to 80° C.) and under a source of hydrogen for 24 to 48 hours, preferably about 36 hours. The catalyst is removed to give the 3,4-dihydrocarbostyril compound of Formula 5c.

Provenance & Evidence