HCID 15676967, compound → HCID 19913752, compound

HRID 1090705Notes

Reaction equation

HRID 1090705 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8](=[O:14])[O:9][CH2:10][CH:11]2[CH2:13][CH2:12]2)[CH2:3][CH2:2]1.[Cl:15][CH2:16][CH2:17][O:18][C:19]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]2[C:20]=1[CH2:21][CH2:22][C:23](=[O:31])[NH:24]2>>[ClH:15].[CH3:30][O:29][C:26]1[CH:27]=[CH:28][C:19]([O:18][CH2:17][CH2:16][N:1]2[CH2:2][CH2:3][CH:4]([NH:7][C:8]([O:9][CH2:10][CH:11]3[CH2:12][CH2:13]3)=[O:14])[CH2:5][CH2:6]2)=[C:20]2[C:25]=1[NH:24][C:23](=[O:31])[CH2:22][CH2:21]2

Participants

3

Reactant 2

HCID 15676967HCID 15676967, compoundHCID 15676990HCID 15676990, compound

Product 1

HCID 19913752HCID 19913752, compound

Procedure

Proceeding as in part A above, but replacing isobutyl 4-piperidylcarbamate with cyclopropylmethyl 4-piperidylcarbamate, and replacing 5-(3-chloropropoxy)-3,4-dihydrocarbostyril with 5-(2-chloroethoxy)-3,4-dihydro-8-methoxycarbostyril there was obtained 8-methoxy-3,4-dihydro-5-[2-(4-((cyclopropylmethoxy)carbonylamino)-1-piperidyl)ethoxy]carbostyril hydrochloride, m.p. 218°-220° C.

Sources & evidence

ORD record
ord-daf8daf46a9f4ce1851dfedb46980b26
Source dataset
uspto-grants-1992_01
Patent number
US05082847

Reaction notes

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