Acetic Anhydride → HCID 15677066, compound

Participants

Reaction Steps

3,4-Dihydro-5-[2-hydroxy-3-(4-(isobutoxycarbonylamino)-1-piperidyl)propoxy]carbostyril (3 g) was dissolved in pyridine (30 mL) and acetic anhydride (0.9 mL) was added dropwise with stirring. After the addition, the mixture was stirred at room temperature for 12 hours, and the pyridine was then evaporated under reduced pressure. The residue was dissolved in chloroform (100 mL) and the organic solution was washed twice with water (50 mL each) and dried over sodium sulfate. The solvent was then evaporated and the residue recrystallized from isopropyl ether to yield 1.5 g of the title compound, 3,4-dihydro-5-[2-acetyloxy-3-(4-(isobutoxycarbonylamino)-1-piperidyl)propoxy]carbostyril, m.p. 120° C.

Provenance & Evidence