2-cyano-8-(4-(quinolin-2-ylmethoxy)phenoxymethyl)-4-oxo-4H-1-benzopyran → HCID 178515801, compound

HRID 1090788Notes

Reaction equation

HRID 1090788 reaction equation
[C:1]([C:3]1[O:4][C:5]2[C:13]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]4[CH:33]=[CH:32][C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[N:25]=4)=[CH:18][CH:17]=3)=[CH:12][CH:11]=[CH:10][C:6]=2[C:7](=[O:9])[CH:8]=1)#[N:2].[NH:34]1C=N[N:36]=[N:35]1>>[N:25]1[C:26]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:32]=[CH:33][C:24]=1[CH2:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][CH2:14][C:13]2[C:5]3[O:4][C:3]([C:1]4[NH:36][N:35]=[N:34][N:2]=4)=[CH:8][C:7](=[O:9])[C:6]=3[CH:10]=[CH:11][CH:12]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 199138832-cyano-8-(4-(quinolin-2-ylmethoxy)phenoxymethyl)-4-oxo-4H-1-benzopyranHCID 178418441HCID 178418441, compound

Product 1

HCID 178515801HCID 178515801, compound

Procedure

When the nitrile of Example 12, Step 7 is replaced with the cyano product from Example 33, Step 4 above, 5- 8-(4-(quinolin-2-ylmethoxy)phenoxymethyl)-4-oxo-4H-1- benzopyran-2-yl)tetrazole is obtained; m.p. >250° C.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-28b9ce1753254f9595f44168b536de58
Source dataset
uspto-grants-1992_01
Patent number
US05082849

Reaction notes

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