Water → HCID 9935613, compound

Participants

Reaction Steps

2.6 g of ethyl-3-(7-(3-(quinolin-2-ylmethoxy)- benzyloxy)-3,4-dihydro-2-methyl-4-oxo-2H-1-benzopyran-2yl)propanoate and 1.02 g of lithium hydroxide hydrate are combined in 30 ml of methanol, 30 ml of tetrahydrofuran and 10 ml of water and stirred at room temperature for 3 hours. The solvent is removed by evaporation and the residue diluted with water and washed with ether. The pH of the aqueous portion is adjusted to 5 and the suspension extracted with ethyl acetate. The dried ethyl acetate solution is concentrated and the residue purified by chromatography on silica gel to give 0.85 g of 3-(7-(3- (quinolin-2-ylmethoxy)benzyloxy)-3,4-dihydro-2-methyl-4- oxo-2H-1-benzopyran-2-yl)propanoic acid; m.p. 152°-54° C.

Provenance & Evidence