反应详情

To a solution of 1.5 g (15 mmol) of 2-mercaptoimidazole in 15 ml of ethanol was added at room temperature 2.66 g (15 mmol) of 2-aminobenzyl chloride hydrochloride. The mixture was then stirred for one hr. at room temperature. The obtained homogeneous solution was placed under reduced pressure at a temperature below 40° C. to distill off the solvent. To the residue were successively added water and saturated aqueous sodium hydrogencarbonate to precipitate a crystalline product. The product was collected by filtration, washed twice with water, and dried to give 2.5 g of the desired compound as a pale gray crystalline product, yield 80.9%.

1. customat room temperature
2. customwas placed under reduced pressure at a temperature below 40° C.
3. distillationto distill off the solvent
4. customto precipitate a crystalline product
5. filtrationThe product was collected by filtration
6. washwashed twice with water
7. customdried