Tetrahydrofuran → HCID 86745414, compound

Participants

Reaction Conditions

Reaction Steps

cis-13-Octadecen-3-yn-2-ol was synthesized in the following manner. Thus, a Grignard mixture containing 1.0 mole of methyl magnesium chloride dissolved in 300 ml of tetrahydrofuran was added dropwise into 153 g (0.81 mole) of 8-bromo-1-octyne kept at 50° to 55° C. and the reaction mixture was agitated for 1 hour at 60° C. followed by the addition of 2 g of copper (I) iodide CuI. Thereafter, a second Grignard mixture containing 1.0 mole of cis-3-octenyl magnesium chloride dissolved in 300 ml of tetrahydrofuran was added dropwise to the reaction mixture kept at 40° to 55° C. and the reaction mixture was agitated for 4 hours at 40° C.

Provenance & Evidence