Tetrahydrofuran → HCID 11821510, compound

Participants

Reaction Steps

cis-13-Octadecen-2-yn-1-ol was synthesized in the following manner. Thus, 153 g (0.81 mole) of 8-bromo-1-octyne were added dropwise at 50° to 55° C. to 1 mole of methyl magnesium chloride dissolved in 300 ml of tetrahydrofuran and the mixture was agitated for 1 hour followed by the addition of 2 g of dilithium tetrachlorocuprate Li2CuCl4. Thereafter, a solution of 1 mole of cis-4-nonenyl magnesium chloride dissolved in 300 ml of tetrahydrofuran was added dropwise to the reaction mixture at 40° to 55° C. and the mixture was agitated for 4 hours at 48° C.

Provenance & Evidence